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  "Package": "braidrm",
  "Title": "Fitting Combined Action with the BRAID Response Surface Model",
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  "Authors@R": "c(\nperson(\"Anang\", \"Shelat\", email = \"anang.shelat@stjude.org\", role = c(\"aut\")),\nperson(\"Nathaniel R.\", \"Twarog\", email =\"nathaniel.twarog@stjude.org\", role = c(\"aut\", \"cre\")))",
  "Description": "Contains functions for evaluating, analyzing, and fitting\ncombined action dose response surfaces with the Bivariate\nResponse to Additive Interacting Doses (BRAID) model of\ncombined action, along with tools for implementing other\ncombination analysis methods, including Bliss independence,\ncombination index, and additional response surface methods.",
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  "Maintainer": "Nathaniel R. Twarog <nathaniel.twarog@stjude.org>",
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    "extra/citation.html",
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    "blissReference",
    "braidrm",
    "calcBraidBootstrap",
    "calcBraidConfInt",
    "deviationSurface",
    "estimateChouIndex",
    "estimateChouIndices",
    "estimateCombinationIndex",
    "estimateCombinationIndices",
    "estimateFlippedIAE",
    "estimateIAE",
    "evalBraidModel",
    "evalFlippedBraidModel",
    "evalMusycModel",
    "evalUrsaModel",
    "findBestBraid",
    "fitBraidFlipped",
    "fitCoactiveBraid_partial",
    "fitCoactiveBraid_pure",
    "fitMusycModel",
    "fitOppositionalBraid_A",
    "fitOppositionalBraid_B",
    "fitProtectiveBraid_A",
    "fitProtectiveBraid_B",
    "fitUrsaModel",
    "hsaDeviation",
    "hsaReference",
    "invertBraidModel",
    "invertBraidModel_A",
    "invertBraidModel_B",
    "invertFlippedBraidModel",
    "invertFlippedBraidModel_A",
    "invertFlippedBraidModel_B",
    "kappaPrior",
    "loeweDeviation",
    "loeweReference",
    "referenceSurface",
    "zipDeviation",
    "zipReference",
    "zipSmoothed"
  ],
  "_datasets": [
    {
      "name": "additiveExample",
      "title": "Example Additive Surface",
      "object": "additiveExample",
      "class": [
        "tbl_df",
        "tbl",
        "data.frame"
      ],
      "fields": [
        "concA",
        "concB",
        "truth",
        "measure"
      ],
      "rows": 64,
      "table": true,
      "tojson": true
    },
    {
      "name": "antagonisticExample",
      "title": "Example Antagonistic Surface",
      "object": "antagonisticExample",
      "class": [
        "tbl_df",
        "tbl",
        "data.frame"
      ],
      "fields": [
        "concA",
        "concB",
        "truth",
        "measure"
      ],
      "rows": 64,
      "table": true,
      "tojson": true
    },
    {
      "name": "coactiveExample",
      "title": "Example Coactive Surface",
      "object": "coactiveExample",
      "class": [
        "tbl_df",
        "tbl",
        "data.frame"
      ],
      "fields": [
        "concA",
        "concB",
        "truth",
        "measure"
      ],
      "rows": 64,
      "table": true,
      "tojson": true
    },
    {
      "name": "incompleteExample",
      "title": "Example Partial or Incomplete Surface",
      "object": "incompleteExample",
      "class": [
        "tbl_df",
        "tbl",
        "data.frame"
      ],
      "fields": [
        "concA",
        "concB",
        "truth",
        "measure"
      ],
      "rows": 64,
      "table": true,
      "tojson": true
    },
    {
      "name": "oppositionalExample",
      "title": "Example Oppositional Surface",
      "object": "oppositionalExample",
      "class": [
        "tbl_df",
        "tbl",
        "data.frame"
      ],
      "fields": [
        "concA",
        "concB",
        "truth",
        "measure"
      ],
      "rows": 64,
      "table": true,
      "tojson": true
    },
    {
      "name": "protectiveExample",
      "title": "Example Protective Surface",
      "object": "protectiveExample",
      "class": [
        "tbl_df",
        "tbl",
        "data.frame"
      ],
      "fields": [
        "concA",
        "concB",
        "truth",
        "measure"
      ],
      "rows": 64,
      "table": true,
      "tojson": true
    },
    {
      "name": "synergisticExample",
      "title": "Example Synergistic Surface",
      "object": "synergisticExample",
      "class": [
        "tbl_df",
        "tbl",
        "data.frame"
      ],
      "fields": [
        "concA",
        "concB",
        "truth",
        "measure"
      ],
      "rows": 64,
      "table": true,
      "tojson": true
    }
  ],
  "_help": [
    {
      "page": "additiveExample",
      "title": "Example Additive Surface",
      "topics": [
        "additiveExample"
      ]
    },
    {
      "page": "antagonisticExample",
      "title": "Example Antagonistic Surface",
      "topics": [
        "antagonisticExample"
      ]
    },
    {
      "page": "braidrm",
      "title": "BRAID Response Surface Fitting",
      "topics": [
        "braidrm",
        "braidrm.default",
        "braidrm.formula",
        "print.braidrm",
        "print.summary.braidrm",
        "summary.braidrm"
      ]
    },
    {
      "page": "calcBraidBootstrap",
      "title": "BRAID Parameter Confidence Intervals",
      "topics": [
        "calcBraidBootstrap"
      ]
    },
    {
      "page": "calcBRAIDconfint",
      "title": "Generic BRAID confidence intervals",
      "topics": [
        "calcBraidConfInt"
      ]
    },
    {
      "page": "coactiveExample",
      "title": "Example Coactive Surface",
      "topics": [
        "coactiveExample"
      ]
    },
    {
      "page": "deviationSurface",
      "title": "Non-interacting Reference Surfaces",
      "topics": [
        "blissDeviation",
        "blissReference",
        "deviationSurface",
        "hsaDeviation",
        "hsaReference",
        "loeweDeviation",
        "loeweReference",
        "referenceSurface",
        "zipDeviation",
        "zipReference",
        "zipSmoothed"
      ]
    },
    {
      "page": "estimateCombinationIndices",
      "title": "Combination Index",
      "topics": [
        "estimateChouIndex",
        "estimateChouIndices",
        "estimateCombinationIndex",
        "estimateCombinationIndices"
      ]
    },
    {
      "page": "estimateIAE",
      "title": "BRAID Response Surface Combined Potency",
      "topics": [
        "estimateFlippedIAE",
        "estimateIAE",
        "estimateIAE.braidrm",
        "estimateIAE.braidrmflip",
        "estimateIAE.default"
      ]
    },
    {
      "page": "evalBraidModel",
      "title": "Evaluate the BRAID response surface model",
      "topics": [
        "evalBraidModel"
      ]
    },
    {
      "page": "evalFlippedBraidModel",
      "title": "Evaluate Flipped BRAID Surfaces",
      "topics": [
        "evalFlippedBraidModel"
      ]
    },
    {
      "page": "evalMusycModel",
      "title": "Evaluate MuSyC Response Surfaces",
      "topics": [
        "evalMusycModel"
      ]
    },
    {
      "page": "evalUrsaModel",
      "title": "Evaluate URSA response surface model",
      "topics": [
        "evalUrsaModel"
      ]
    },
    {
      "page": "findBestBRAID",
      "title": "Select Best BRAID Response Fit",
      "topics": [
        "findBestBraid",
        "findBestBraid.default",
        "findBestBraid.formula"
      ]
    },
    {
      "page": "fitBraidFlipped",
      "title": "Fit Flipped BRAID Surfaces",
      "topics": [
        "fitBraidFlipped",
        "fitCoactiveBraid_partial",
        "fitCoactiveBraid_pure",
        "fitOppositionalBraid_A",
        "fitOppositionalBraid_B",
        "fitProtectiveBraid_A",
        "fitProtectiveBraid_B"
      ]
    },
    {
      "page": "fitMusycModel",
      "title": "MuSyC Response Surface Fitting",
      "topics": [
        "fitMusycModel",
        "fitMusycModel.default",
        "fitMusycModel.formula"
      ]
    },
    {
      "page": "fitUrsaModel",
      "title": "URSA Response Surface Fitting",
      "topics": [
        "fitUrsaModel",
        "fitUrsaModel.default",
        "fitUrsaModel.formula"
      ]
    },
    {
      "page": "incompleteExample",
      "title": "Example Partial or Incomplete Surface",
      "topics": [
        "incompleteExample"
      ]
    },
    {
      "page": "invertBraidModel",
      "title": "Invert a BRAID Response Surface Model",
      "topics": [
        "invertBraidModel",
        "invertBraidModel_A",
        "invertBraidModel_B"
      ]
    },
    {
      "page": "invertFlippedBraidModel",
      "title": "Invert Flipped BRAID Surfaces",
      "topics": [
        "invertFlippedBraidModel",
        "invertFlippedBraidModel_A",
        "invertFlippedBraidModel_B"
      ]
    },
    {
      "page": "kappaPrior",
      "title": "Braid kappa Bayesian Prior",
      "topics": [
        "kappaPrior"
      ]
    },
    {
      "page": "oppositionalExample",
      "title": "Example Oppositional Surface",
      "topics": [
        "oppositionalExample"
      ]
    },
    {
      "page": "protectiveExample",
      "title": "Example Protective Surface",
      "topics": [
        "protectiveExample"
      ]
    },
    {
      "page": "synergisticExample",
      "title": "Example Synergistic Surface",
      "topics": [
        "synergisticExample"
      ]
    }
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  "_pkglogo": "https://github.com/nathanieltwarog/braidrm/raw/HEAD/man/figures/logo.png",
  "_readme": "https://github.com/nathanieltwarog/braidrm/raw/HEAD/README.md",
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      "title": "Additional Approaches",
      "engine": "knitr::rmarkdown",
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        "Introduction",
        "Response Surface Methods",
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